People Matter

Principal Instrument Architect

Loop Genomics

Loop Genomics

IT
San Diego, CA, USA
USD 156k-221k / year + Equity
Posted on Aug 6, 2025

At Element Biosciences, we are passionate about our mission to empower the scientific community with more freedom and flexibility to accelerate our collective impact on humanity. We have built a highly efficient product-driven organization where employees can learn, grow, and thrive in a challenging but encouraging environment. We are committed to scientific integrity, collegiality, honesty, objectivity, and openness.

We are seeking an experienced Principal Instrument Architect to drive system architecture, module design, simulation, and optimization for complex scientific instruments. This is a key role within our Instrument Mechanical Engineering group requiring a technical expert with previous experience collaborating closely with cross-functional teammates from R&D and Operations. Strong engineering fundamentals in motion systems, thermal, and static analysis, rigorous critical thinking skills, and a methodical product development approach are essential attributes. This role will report to our SVP of Engineering and will be an on-site San Diego basedrole.

If you possess the following and want to make a meaningful impact, we invite you to explore this role.

Essential Functions and Responsibilities:

  • Translate market requirements into product requirements, system architecture, module designs, and component selection
  • Design functional electro-mechanical modules that integrate into a rational system architecture
  • Negotiate system performance trade-offs across structural, motion, thermal, fluidic, and optical domains
  • Manage internal and external development projects; evaluate and select vendors and design partners
  • Lead cross-functional root cause analysis involving shock, vibration, noise, thermal gradients, and control loops by applying structured problem-solving methodologies and making data-driven decisions
  • Verify and transfer reliable system architectures and control solutions from R&D to Operations; Support existing product lines as required
  • Lead improvement efforts to optimize instrument performance, lifetime, reliability, and robustness against external forces
  • Steer and support the company’s product development roadmap by proving out new architectures, technologies, and design concepts

Education and Experience:

  • Minimum BS degree in Mechanical Engineering or Mechatronics and 16 or more years relevant work experience (or equivalent combination of education and industry experience)
  • Proven track record as a system architect on development programs spanning from concept to commercialization
  • Strong applied understanding of motion control theory (PID feedback, Bode plots) and motion control design principles (stage / cradle / isolator design, kinematics, dynamics modeling)
  • Expertise with SolidWorks and SolidWorks Simulation (or equivalents like Ansys and SIMULIA) required.
  • Experience with programming in C#, LabView, Python, or .NET preferred
  • Scientifically curious, a critical thinker, with a passion for learning new things
  • Relentlessly seeks to understand the scientific root cause of different aspects of system performance and to steer that understanding towards design improvements
  • Ability to navigate uncertainty while developing a deeper understanding of system performance to enable development of better products
  • Ability to work in a fast paced, interdisciplinary environment and quickly adjust to rapidly evolving technology and priorities

Physical Requirements:

  • Must be able to operate industrial machinery.
  • Ability to lift up to 20 pounds
  • Must be flexible in working hours as this position may require customer/vendor support during non-regular business hours

Location:

  • San Diego – on-site

Travel:

  • Up to 10% or as needed

Job Type:

  • Full-time, Exempt

Base Compensation Pay Range:

  • $156,000 - $221,000

In addition to base compensation noted above, you will be eligible for stock options, discretionary annual bonus, no cost health insurance plans, 401k with company match, and flexible paid time off.

Please note: Base compensation will depend on multiple factors, including geographic location, qualifications, and experience.

We foster an environment such that all people are afforded the freedom to pursue their passions without regard to race, color, religion, national or ethnic origin, gender (including pregnancy), sexual orientation, gender identity or expression, age, disability, veteran status or any other characteristics protected by law.