Mammalian Synthetic Biologist
Nabla Bio
Send a CV and why you're interested in working with us to hiring@nabla.bio.
About
Our mission is to generate new therapeutic opportunities by advancing AI and experimental technologies for drug design. Using AI and massively parallel experimentation, we design antibodies that precisely bind the disease target at the right location, while minimizing manufacturability and toxicity risks. We are a well-funded, revenue-generating, bilingual company of wet- and dry-lab scientists, and are founded by AI and protein design experts from Harvard University.
The role
Fueled by partnerships and increasing demand for internal R&D, we will be looking to you develop and perform high-throughput and multiplex cell-based assays for evaluating antibody function. This will include:
- Engineering transient and stable cell lines with diverse reporters in both model and disease systems
- Collecting and analyzing quantitative measurements using flow cytometry, immunoassays, -omics (pooled, single cell), and other techniques.
- Prioritizing top development candidates by functional and binding characterization
- Working together with our dry-lab and other wet-lab scientists to establish a rapid and seamless testing pipeline for characterizing machine learning generated antibody designs
Qualifications
- PhD-level knowledge and experience in mammalian synthetic biology and cellular assay development
- Extensive experience in molecular biology: plasmid design, single-insert cloning, library cloning, bacterial transformation and culturing.
- Extensive experience in cell line engineering and tissue culture. Includes experience with transient and stable transfections, lentiviral transduction, electroporation; and, experience troubleshooting biological readouts. Experience culturing a wide variety of immortalized and primary disease cells is a plus.
- Well-organized, and would enjoy establishing an operationally efficient engineering and characterization pipeline that works reliably
- Problem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlines
- Value unblocking colleagues before yourself, and are excited to mentor/train junior colleagues