People Matter

Senior Biochemist - Phage Manufacturing and Process Development - Microbiology and Early CMC team

Eligo Bioscience

Eligo Bioscience

Paris, France
Posted on Thursday, June 13, 2024

// ABOUT ELIGO

Eligo Bioscience’s mission is to develop precision medicines to address serious unmet medical needs in the field of inflammatory diseases, infectious diseases and oncology.

Backed by top-tier investors from Silicon Valley and Europe, Eligo is an industry-leading biotechnology company, co-founded by scientists and professors from MIT and the Rockefeller University – now operating in Paris, France. We are progressing next-generation precision medicines through in vivo gene editing of the microbiome.

Our pioneering work in the field of synthetic biology has enabled Eligo to be elected as one of the 30 Most Innovative Companies by the World Economic Forum, to receive multiple prestigious international awards. We have also been featured in international media and scientific journals such as Nature Biotechnology, Science, The Economist, The BBC and The New York Times.

Eligonauts are driven, passionate, and motivated to impact the lives of patients by applying cutting-edge science to solve real unmet needs. We are at a very exciting point in time of the Eligo journey as we are embarking on the transition from a start-up deeply rooted in innovation to a clinical stage biotech with the objective to bring our lead program to the clinic within the next two years.. In this context we are looking for a high-performing and enthusiastic Biochemist with microbiology expertise to join the microbiology and early CMC team to support the transition of our program’s to manufacturing.

Eligo Bioscience has attracted highly-diverse top talent from all over the world, who are driven, passionate, and motivated to impact the lives of patients by applying cutting-edge science to save lives and treat chronic disease. Eligo embraces diversity, equal opportunity and inclusion and is committed to building diverse teams in a fast-paced environment fostering scientific excellence and benevolence.

// YOUR MISSION

At Eligo Bioscience, we are passionate about developing new drugs to address microbiome-associated unmet medical needs! As part of the Microbiology and Early CMC team you will contribute to:

  • the characterization of bacteria, phages and Eligobiotics to support the development of drug candidate
  • the development of USP (fermentation), DSP (purification) and analytical methods to support manufacturing of our Eligobiotics particles.

// POSITION SUMMARY

The Microbiology and early CMC scientist will join a team of scientists with strong experience in microbiology, molecular biology and manufacturing. The scientist will interact strongly with:

  • the head of CMC and the external partners in charge of the manufacturing and analytical characterization.
  • the other research teams to support the development of Eligobiotics

The scientist will report to the head of the Microbiology and Early CMC team.

// RESPONSIBILITIES

  • Design, execute, and oversee hands-on experiments to develop production (USP), purification (DSP) and analytical process/methods
  • Design, execute, and oversee hands-on experiments to characterize target bacteria, Eligobiotics producer bacteria, phages and Eligobiotics
  • Participate to technical Transfer USP, DSP and analytical process/methods to cGMP CDMO
  • Supervise external partners to develop USP, DSP, analytical methods
  • Support CMC department to build CMC development plan
  • Analyze, interpret, and effectively communicate experimental findings at various meetings involving multidisciplinary teams and/or collaborators.
  • Independently plan experimental paths forward, proactively develop and/or optimize methods, and incorporate new technology/techniques into practice.
  • Prepare comprehensive reports and presentation materials as necessary, and maintain meticulous experimental documentation in electronic lab notebooks in accordance with Eligo’s working practice.
  • Contribute to scientific review meetings and assist in drafting relevant sections of regulatory documents as needed.
  • Foster a collaborative and supportive environment, aiding in the development and well-being of fellow team members while also participating in general lab support operations.
  • Stay aware of recent advancements in the field through literature review and dissemination of data via presentations at scientific conferences when appropriate.

// APPLICANT PROFILE

Technical skills

  • PhD in Biochemistry with strong Microbiology expertise and 3 years of experience
  • Previous experience in a biologics (ideally bacteriophages or other viral particles) production, purification and associated analytical methods in biotech/CDMO or laboratory
  • Deep knowledge and hands-on experience in the field of biochemistry and microbiology
  • Hands-on experience in chromatography (Biorad NGC system, Akta system, …) purification
  • Hands-on experience with bioreactors is a plus

Knowledge regarding CMC development

  • Experience in designing and analyzing experiments of Liquid chromatography Mass spectrometry (LC-MS) or analytical ultracentrifugation
  • Ability to develop methods, processes and to transfer to external partners (CDMO) with rigorous documentation
  • Experience in managing relationships with external collaborators
  • Ability to design and run experiments, interpret data, troubleshoot, suggest next steps and identify alternative approaches.
  • Ability to deliver high-quality, consistent results in a timely fashion.
  • Experience in microbiology techniques with bacteria and ideally bacteriophages
  • Self-motivated, creative and critical thinker with a ‘can-do’ attitude eager to contribute to the development of novel therapeutics
  • Independent, proactive, and with a strong sense of accountability.
  • Flexible, adaptable, open to new ideas and able to function under pressure.
  • Meticulous, rigorous, result-oriented and committed to scientific integrity and ethics
  • Outstanding organization skills, time management, and able to prioritize tasks across multiple projects in a fast-paced environment.
  • Effective team player with excellent interpersonal skills
  • Experience with QMS : Quality management System

Join us as we build the future of precision microbiome medicines!