Eligo Bioscience, backed by top-tier investors from Silicon Valley and Europe, is pioneering next-generation microbiome therapeutics. Co-founded by MIT and Rockefeller University scientists, Eligo is headquartered in Paris, France. Our mission is to address unmet medical needs in inflammatory and infectious diseases, as well as oncology, through groundbreaking gene-editing medicines.

Our first-in-class synthetic biology platform has earned Eligo numerous international awards and recognition, including being named one of the World Economic Forum’s “30 Most Innovative Companies” and has been featured in international press Nature, Science, The Economist, BBC, The New York Times, etc.

More recently, our latest work pas published in Nature this summer (In situ targeted base editing of bacteria in the mouse gut)

— Organization Context // Why Join Us? —

With over $50M in funding (including a recent $35M Series B), we’re well-positioned for our next major milestones: advancing our first drug in clinical trials by 2026, progressing a stealth project with a Top-10 Pharma partner, and exploring new applications for our technology.

Our team of 30+ “Eligonauts” is deeply invested in pushing scientific boundaries within a vibrant, collaborative culture. We embrace diversity, equal opportunity and inclusion and are committed to building diverse teams in a fast-paced environment fostering scientific excellence and benevolence.

— The role —

As part of the Microbiology and Early CMC team, you will contribute to the characterization of bacteria, phages and Eligobiotics to support the development of drug candidate, as well as the development of USP (fermentation), DSP (purification) and analytical methods to support manufacturing of our Eligobiotics particles.

You will join a team of scientists with strong experience in microbiology, molecular biology and manufacturing. You will interact frequently with:

the head of CMC and the external partners in charge of the manufacturing and analytical characterization.
the other research teams to support the development of Eligobiotics

You will report to the head of the Microbiology and Early CMC team.

— Key Responsibilities —

Design, execute, and oversee hands-on experiments to develop production (USP), purification (DSP) and analytical process/methods
Design, execute, and oversee hands-on experiments to characterize target bacteria, Eligobiotics producer bacteria, phages and Eligobiotics
Participate to technical Transfer USP, DSP and analytical process/methods to cGMP CDMO
Supervise external partners to develop USP, DSP, analytical methods
Support CMC department to build CMC development plan
Analyze, interpret, and effectively communicate experimental findings at various meetings involving multidisciplinary teams and/or collaborators.
Independently plan experimental paths forward, proactively develop and/or optimize methods, and incorporate new technology/techniques into practice.
Prepare comprehensive reports and presentation materials as necessary, and maintain meticulous experimental documentation in electronic lab notebooks in accordance with Eligo’s working practice.
Contribute to scientific review meetings and assist in drafting relevant sections of regulatory documents as needed.
Foster a collaborative and supportive environment, aiding in the development and well-being of fellow team members while also participating in general lab support operations.
Stay aware of recent advancements in the field through literature review and dissemination of data via presentations at scientific conferences when appropriate.

— Qualifications —

Technical skills

PhD in Biochemistry with strong Microbiology expertise and 3 years of experience
Previous experience in a biologics (ideally bacteriophages or other viral particles) production, purification and associated analytical methods in biotech/CDMO or laboratory
Deep knowledge and hands-on experience in the field of biochemistry and microbiology
Hands-on experience in chromatography (Biorad NGC system, Akta system, …) purification
Hands-on experience with bioreactors is a plus

Knowledge regarding CMC development

Experience in designing and analyzing experiments of Liquid chromatography Mass spectrometry (LC-MS) or analytical ultracentrifugation
Ability to develop methods, processes and to transfer to external partners (CDMO) with rigorous documentation
Experience in managing relationships with external collaborators
Ability to design and run experiments, interpret data, troubleshoot, suggest next steps and identify alternative approaches.
Ability to deliver high-quality, consistent results in a timely fashion.
Experience in microbiology techniques with bacteria and ideally bacteriophages
Self-motivated, creative and critical thinker with a ‘can-do’ attitude eager to contribute to the development of novel therapeutics
Independent, proactive, and with a strong sense of accountability.
Flexible, adaptable, open to new ideas and able to function under pressure.
Meticulous, rigorous, result-oriented and committed to scientific integrity and ethics
Outstanding organization skills, time management, and able to prioritize tasks across multiple projects in a fast-paced environment.
Effective team player with excellent interpersonal skills
Experience with QMS : Quality management System

— Benefits —

Unique advantages and comprehensive benefits:

Competitive salary and equity packages for each employee
4€/day covered by Eligo for lunch expenditures
100% coverage of top-tier health insurance & Mutuelle (Alan) for Eligonauts and their kids
100% of public transportation card costs reimbursed, or 400€/year offered for alternative transport support
Integration assistance: weekly French and English classes covered 100%
Health & Wellness: subscription to top-tier sports and wellness platform
Flexible hours & remote-work policy (2 days per week if compatible with responsibilities)

— Additional perks —

A team that is passionate, creative, driven, and at the top of their game
A fast-paced, international, interdisciplinary, inspiring, and collaborative work environment
An opportunity to apply cutting-edge technologies to solve real-world problems
A truly unique and fantastic company culture
Easily accessible via public transit (metro lines 14 and 6, RER C, tram T3a, various bus lines)
Secure parking for bikes on site
Numerous options for lunch: many restaurants within walking distance, fully-equipped kitchen and cafeteria on the Eligo premises, and a Foodles workplace canteen in the common building space
Last but not least…the Parisian life! (Brand-new lab and office space in Paris with a rooftop terrace from which we can see the Eiffel Tower sparkle ✨; 6-minute walk from the river Seine)

—

If you’re excited to work at the forefront of synthetic biology and gene-editing, in a role that combines scientific rigor with collaborative teamwork, we’d love to hear from you!

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