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Translational Research Scientist Skin Immunology / Microbiology

Eligo Bioscience

Eligo Bioscience

Paris, France
Posted on Wednesday, April 17, 2024

// ABOUT ELIGO

Eligo Bioscience’s mission is to develop precision medicines to address serious unmet medical needs in the field of inflammatory diseases, infectious diseases and oncology.

Backed by top-tier investors from Silicon Valley and Europe, Eligo is an industry-leading biotechnology company, co-founded by scientists and professors from MIT and the Rockefeller University – now operating in Paris, France. We are progressing next-generation precision medicines through in vivo gene editing of the microbiome.

Our pioneering work in the field of synthetic biology has enabled Eligo to be elected as one of the 30 Most Innovative Companies by the World Economic Forum, to receive multiple prestigious international awards. We have also been featured in international media and scientific journals such as Nature Biotechnology, Science, The Economist, The BBC and The New York Times.

Eligonauts are driven, passionate, and motivated to impact the lives of patients by applying cutting-edge science to solve real unmet needs. We are at a very exciting point in time of the Eligo journey as we are embarking on the transition from a start-up deeply rooted in innovation to a clinical stage biotech with the objective to bring our lead program to the clinic within the next two years. In parallel we are also ramping up our efforts in target discovery and early preclinical programs to support the development of new assets from our Eligobiotic platform. In this context we are looking for a high-performing and enthusiastic immunologist or microbiologist with a strong expertise in skin immunity / infectious processes, and experience with translational models to join the Host-Microbiome interactions team and support the development of Eligo’s programs across the portfolio.

Eligo Bioscience has attracted highly-diverse top talent from all over the world, who are driven, passionate, and motivated to impact the lives of patients by applying cutting-edge science to save lives and treat chronic disease. Eligo embraces diversity, equal opportunity and inclusion and is committed to building diverse teams in a fast-paced environment fostering scientific excellence and benevolence.

// YOUR MISSION

At Eligo Bioscience, we are passionate about developing new drugs to address microbiome-associated unmet medical needs! As part of the Host-Microbiome interactions team you will both contribute to the generation of pivotal preclinical data to support the development of Eligo’s programs towards the clinic, and to discovery work supporting the entry of new programs into Eligo portfolio.

// POSITION SUMMARY

The Host-Microbiome interactions scientist will join a team of translational scientists with strong experience in the set up and execution in vitro, ex vivo and in vivo models across various fields (immunology, microbiology, molecular biology, pharmacology) to support preclinical development of Eligo’s programs either internally or in collaboration with external partners. They report to the Senior Director of Host-Microbiome interactions.

// RESPONSIBILITIES

  • Design, execute, and oversee hands-on experiments across in vivo (rodents), ex vivo (human or rodent primary cells and tissues), and in vitro (cell lines, bacterial cultures) models, employing diverse cellular biology, immunology, microbiology, and molecular biology techniques.
  • Analyze, interpret, and effectively communicate experimental findings at various meetings involving multidisciplinary teams and/or collaborators.
  • Independently plan experimental paths forward, proactively develop and/or optimize methods, and incorporate new technology/techniques into practice.
  • Prepare comprehensive reports and presentation materials as necessary, and maintain meticulous experimental documentation in electronic lab notebooks in accordance with Eligo’s working practice.
  • Contribute to scientific review meetings and assist in drafting relevant sections of regulatory documents as needed.
  • Foster a collaborative and supportive environment, aiding in the development and well-being of fellow team members while also participating in general lab support operations.
  • Stay aware of recent advancements in the field through literature review and dissemination of data via presentations at scientific conferences when appropriate.

// APPLICANT PROFILE

Technical skills

  • PhD in Immunology, Microbiology, or related fields with a track record of publications
  • Deep knowledge and hands-on experience in the field of skin immunology, skin microbiology or skin biology
  • Postdoctoral training or previous drug discovery or development experience in a biopharmaceutical setting is advantageous.
  • Hands-on experience in models and assays recapitulating skin and hair follicle structure is advantageous.
  • Outstanding expertise in 2D and 3D cell culture techniques
  • Outstanding expertise in cell isolation from human and rodent primary tissues and blood. Experience in isolation of cells from primary skin tissue is advantageous.
  • Ability to design and run experiments, interpret data, troubleshoot, suggest next steps and identify alternative approaches.
  • Ability to deliver high-quality, consistent results in a timely fashion.
  • Experience in immunological and molecular biology techniques including but not limited to flow cytometry, nucleic acid extraction, qPCR/ddPCR, ELISA, Western Blotting. Proficiency in utilizing functional genomic editing tools (CRISPR-Cas, si/hRNA) is advantageous.

Other skills

  • Self-motivated, creative and critical thinker with a ‘can-do’ attitude eager to contribute to the development of novel therapeutics
  • Independent, proactive, and with a strong sense of accountability.
  • Flexible, adaptable, open to new ideas and able to function under pressure.
  • Meticulous, rigorous, result-oriented and committed to scientific integrity and ethics
  • Outstanding organization skills, time management, and able to prioritize tasks across multiple projects in a fast-paced environment.
  • Effective team player with excellent interpersonal skills
  • Experience in managing relationships with external collaborators is advantageous

    Join us as we build the future of precision microbiome medicines!