Eligo Bioscience, backed by top-tier investors from Silicon Valley and Europe, is pioneering next-generation microbiome therapeutics. Co-founded by MIT and Rockefeller University scientists, Eligo is headquartered in Paris, France. Our mission is to address unmet medical needs in inflammatory and infectious diseases, as well as oncology, through groundbreaking gene-editing medicines.

Our first-in-class synthetic biology platform has earned Eligo numerous international awards and recognition, including being named one of the World Economic Forum’s “30 Most Innovative Companies” and has been featured in international press Nature, Science, The Economist, BBC, The New York Times, etc.

More recently, our latest work pas published in Nature this summer (In situ targeted base editing of bacteria in the mouse gut)

— Organization Context // Why Join Us? —

With over €50M in funding—including €35M raised in the past 12 months—we’re well-positioned for our next major milestones: advancing our first drug in clinical trials by 2026, progressing a stealth project with a Top-10 Pharma partner, and exploring new applications for our technology.

Our team of 30+ “Eligonauts” is deeply invested in pushing scientific boundaries within a vibrant, collaborative culture. We embrace diversity, equal opportunity and inclusion and are committed to building diverse teams in a fast-paced environment fostering scientific excellence and benevolence.

— The role —

As a member of our SynBio team, you’ll be at the forefront of Eligo’s pioneering platform technology, working on the engineering of phage-derived particles (Eligobiotics) that can precisely deliver therapeutic DNA payloads to (re)program various bacterial species directly in the microbiome.

We’re seeking an ambitious and skilled Synthetic Biologist with expertise in non-model bacterial and/or phage engineering to help us design, test, and optimize our next generation of Eligobiotics, and develop microbial cell lines for their production.

This role offers a unique opportunity to explore frontier science, developing and optimizing novel genetic tools and circuits for bacterial species that are largely uncharted. You’ll also engineer innovative DNA delivery systems, advancing in vivo microbiome editing in ways that have never been attempted. In close collaboration with teams in Bioinformatics, Microbiology, In Vivo, and Manufacturing, you’ll help drive forward discoveries that push the boundaries of microbiome editing.

— Key Responsibilities —

Develop and optimize novel genetic tools in non-model bacteria
Build, test, debug and optimize genetic circuits for strain and phage engineering
Tune genetic expression on developed circuits for efficient function of the drug in target bacterial species
Engineer new DNA packaging and delivery systems based on engineered phages
Work hand-in-hand with other scientists to accelerate the process of Eligobiotics engineering

— Qualifications —

Ph.D. in a relevant field (i.e., molecular biology, microbiology, synthetic biology, etc).
Demonstrated experience with state-of-the-art molecular biology techniques (i.e. Gibson, Golden gate or CRISPR, etc)
Demonstrated strong experience with non-model bacteria including anaerobic bacteria
Phage expertise is a plus
Self-starter with strong attention to detail and accuracy and an ability to work independently to solve technical problems
Ability to multitask without compromising quality and accuracy
Effective management of time and effort to meet deadlines
Strong interactive skills and ability to work effectively in a team environment
Strong collaborative attitude essential

— Benefits —

Unique advantages and comprehensive benefits:

Competitive salary and equity packages for each employee
4€/day covered by Eligo for lunch expenditures
100% coverage of top-tier health insurance & Mutuelle (Alan) for Eligonauts and their kids
100% of public transportation card costs reimbursed, or 400€/year offered for alternative transport support
Integration assistance: French and English classes covered 100%
Health & Wellness: subscription to top-tier sports and wellness platform
Flexible hours & remote-work policy (2 days per week if compatible with responsibilities)

— Additional perks —

A team that is passionate, creative, driven, and at the top of their game
A fast-paced, international, interdisciplinary, inspiring, and collaborative work environment
An opportunity to apply cutting-edge technologies to solve real-world problems
A truly unique and fantastic company culture
Easily accessible via public transit (metro lines 14 and 6, RER C, tram T3a, various bus lines)
Secure parking for bikes on site
Numerous options for lunch: many restaurants within walking distance, fully-equipped kitchen and cafeteria on the Eligo premises, and a Foodles workplace canteen in the common building space
Last but not least…the Parisian life! (Brand-new lab and office space in Paris with a rooftop terrace from which we can see the Eiffel Tower sparkle ✨; 6-minute walk from the river Seine)

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If you’re excited to work at the forefront of synthetic biology and gene-editing, in a role that combines scientific rigor with collaborative teamwork, we’d love to hear from you!

Apply now

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