Senior Scientist, Translational Biomarkers
Editas Medicine
Why Choose Editas?
At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!
Decoding The Role:
Editas Medicine is seeking a highly motivated biomarker scientist to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. In this role, you would report to the Sr. Director of Bioanalytical and Biomarker Sciences and developing and executing stage-appropriate protein biomarker assays in support of translational biomarkers, non-clinical safety, and PK/PD studies.
The ideal candidate will have strong technical skills in regulated and non-regulated LBA, PD Biomarker assays, a broad understanding of drug development, IND-enabling activities and ability to work in a matrix team structure. The individual in this role should be an independent thinker, possess a positive and team-centered mindset, and an ability to thrive in a fast-paced environment. Prior experience in gene therapy and with lipid nanoparticle based (LNP) delivery systems and/or nucleic acid therapeutics is highly preferred.
Characterizing Your Impact:
As the Senior Scientist, you will:
- Establish and execute routine workflows for method development using techniques such as LBA assays (ELISA/MSD, Flow cytometry) to support PD and safety biomarker development and apply innovative solutions to solve complex problems in order to advance the pipeline.
- Develop and execute LBA-based methods, sample analysis, data generation, and report writing for preclinical (IND-enabling) and clinical samples.
- Develop and execute cell-based assays in support of translational in vitro studies to highlight MOA or hypothesis-driven nonclinical translational safety questions.
- Design and execute in vitro studies to address efficacy and PD response questions aligned with our overall scientific strategy.
- Execute protein assay strategies to characterize PK/PD, and biodistribution properties of the drug product and address key scientific questions.
- Ensure that the data obtained is of the highest quality, and stage appropriate.
- Write biomarker assay protocols and reports that are suitable for inclusion in registration dossiers.
- Model behaviors of a strong leader and mentor to staff members as appropriate.
- Establish strong partnerships across sites and across functions; Work cross-functionally within the R&D organization.
- Ensure compliance with electronic notebooks (ELN), high data integrity and company policies.
The Ideal Transcript:
To thrive in this role, you’ll need:
- PhD in pharmaceutics, medicinal chemistry, analytical chemistry, or a relevant discipline, with a minimum of 5 years of drug discovery experience; Bachelor’s/Master’s degrees with 11+ years and relevant industry experience will also be considered.
- Extensive knowledge and experience in conducting regulated biomarker analysis using LBA techniques such as ELISA/MSD, Flow cytometry, to support discovery and development projects.
- Demonstrated knowledge and experience in establishing biomarker methods, PK/PD for a variety of therapeutic modalities, ideally in preclinical environment.
- Experience with primary cell cultures, patient-derived specimens, in vitro models to answer disease-relevant questions.
- Experience with formulating and executing forward- and reverse translational questions to address clinically relevant hypothesis.
- Experience in leading and developing strong, technical, delivery-focused teams is a plus.
- Experience with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desired.
- Excellent communication skills and proven ability to collaborate with interdisciplinary teams, along with exceptional scientific thinking and problem-solving skills.
- Ability to multi-task to meet research and development goals in a fast-paced environment.
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
Salary Range:
$150,000 - $170,000
Pay Transparency
Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices.
Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.