Associate Scientist, Platform Technology
Editas Medicine
At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.
We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.
Together, we are leading the way towards a healthier and more equitable future.
Position Summary
Editas is seeking a highly motivated Associate Scientist to join our Platform Technology Group. In this role, you will use various CRISPR delivery systems to execute high-throughput screens, and extract samples for NGS (DNA), RT-ddPCR (RNA) and protein (flow or Western blots/Jess automated blots) readouts to identify lead guides across our internal and external programs. You will track screens through the LIMs and document in your ELN and be responsible for the analysis and summary of the screens to inform follow-up experiments. An ideal candidate should have a strong background in immortalized (hepatocytes) and primary cell culture (HSC, T cells) and have experience screening in these cell types using various CRISPR delivery systems, including RNPs and LNPs.
Key Responsibilities:
- As the Associate Scientist I, Platform Technology, you will be responsible for:
- Lead guide design, screening and selection of lead guide using editing and/or function assays for internal and external partner programs.
- Analyze and summarize screening results into proper documentation (ELN, Study Reports)
- Implementation of a high-through LNP screening workflow, including automated LNP-formulations
- Assist with RNP complexation and perform QC for internal program use