Senior Scientist, Molecular Bioanalytics
Editas Medicine
At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.
We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.
Together, we are leading the way towards a healthier and more equitable future.
Position Summary
Editas Medicine is seeking a highly motivated bioanalytical scientist to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. In this role, you would report to the Sr. Director of DMPK and Bioanalytical Sciences and be responsible for supporting ADME, biodistribution, PK/PD and bioanalytical activities.
This individual will be responsible for developing and executing stage-appropriate molecular bioanalytical assays in support of DMPK, tox, biodistribution and PK/PD studies. The ideal candidate will have strong technical skills in PCR-based methods (ddPCR and/or TaqMan PCR), a broad understanding of drug discovery and development, and ability to work collaboratively with key partners in a matrix team structure. The individual in this role should be an independent thinker, possess a positive and team-centered mindset, and an ability to thrive in a fast-paced environment. Prior experience in gene therapy and with lipid nanoparticle based (LNP) delivery systems and/or nucleic acid therapeutics is a plus
Key Responsibilities:
As the Sr. Scientist Bioanalytical, you will be responsible for:
- Establishing and executing on routine workflows for method development using techniques such as molecular bioanalytical assays (qPCR, ddPCR) to support quantitative bioanalysis and apply innovative solutions to solve complex problems to advance the pipeline.
- Develop and execute PCR-based methods, sample analysis, data generation, and report writing for preclinical and clinical samples.
- Develop nucleic acid extraction (DNA/RNA) and quantification from a broad-spectrum animal tissues.
- Responsible for the design and execution of in vitro and in vivo studies to address ADME questions aligned with our overall scientific strategy.
- Execute bioanalytical assay development strategies to characterize ADME, PK and biodistribution properties of the drug product and address key scientific questions.
- Ensure that the data obtained is of the highest quality, and stage appropriate.
- Write bioanalytical assay protocols and reports that are suitable for inclusion in registration dossiers.
- Contribute effectively to patents, reports, and publications of scientific findings.
- Model behaviors of a strong leader and mentor to staff members as appropriate.
- Establish strong partnerships across sites and across functions; Work cross-functionally within the R&D organization.
- Ensure compliance with electronic notebooks (ELN), high data integrity and company policies.