Senior Scientist, LNP Formulation and Delivery Technology
Editas Medicine
At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.
We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.
Together, we are leading the way towards a healthier and more equitable future.
Position Summary
The Delivery and Editing Technologies Team optimizes current and new editing and delivery technology formats to provide the best in vivo delivery and gene editing solutions for current and future therapeutic programs and is looking to add highly talented and motivated candidate to help develop our lipid nanoparticle (LNP) platform for advancing new therapies. This individual will lead the development of the lipid nanoparticle (LNP) formulation process and produce LNP-encapsulated gene editing agents to support company’s in vitro and in vivo pre-clinical studies. In addition, they will support the characterization assays for LNP batches and show a passion for developing delivery strategies suitable for clinical investigation. With a strong background in LNP formulation and characterization this person will work within cross-functional product development teams including Formulation Development, mRNA Process Development, Analytical Development, Engineering and Quality in development and commercialization of gene therapy drug products.
Key Responsibilities:
As the Senior Scientist, LNP Formulation and Delivery Technology, you will be responsible for:
- Develop and optimize the LNP formulations, including the potential inclusion of targeting moieties, to support pre-clinical in vivo delivery animal studies
- Formulate mRNAs, guide RNAs, and other nucleic acid modalities to support company’s in vitro and in vivo pre-clinical studies
- Characterization of LNPs to support transition to process development groups
- Play an important role in equipment design for scale up LNPs-mRNA production to required scales, for both pre-clinical and clinical development
- Coordinate with the chemistry group at the Boulder site to ensure smooth technology transfer between our chemistry and in vivo teams
- Successfully manage direct reports to achieve company LNP goals
- Maintain a detailed electronic lab notebook and documentation records