People Matter

Research Associate or Senior Research Associate, Therapeutics



Redwood City, CA, USA
Posted on Friday, May 31, 2024

About Earli

Earli exists to make cancer a benign experience. Earli does that by turning cancers against themselves: genetically forcing them to reveal themselves early, and then kill themselves – precisely and clearly distinguishable from benign lesions at early stages. Based on original technology from Stanford’s renowned Gambhir lab, Earli designs genetic constructs that are injected intravenously that turn cancer cells against themselves. These programmable synthetic promoter-reporter sequences “flip on” like light switches only in dysregulated cancer cells and turn them into "factories." The cancer is forced to produce either an epitope “docking station” for imaging agents, or a cytokine for immune system activation against the tumor. Thus, Earli’s platform enables immediate diagnosis and treatment of early cancers, rather than long-term observation that can lead to deadly metastatic recurrence.

Earli's synthetic target expression platform has evolved over five years of deep bioengineering. The system can now detect broad ranges of patient mutations, distinguish between malignant and benign lesions, and offer independence from often elusive natural biomarkers.

Earli has raised $82m in three rounds from investors including Andreessen Horowitz, Khosla Ventures, Emerson Collective, Stanford, Perceptive Advisors, Casdin Capital, Marc Benioff, Sands Capital, Breyer Capital, Tailwinds (American-Korean) etc.

Its Scientific Advisory Board includes Jim Allison (Nobel Laureate, Immuno Oncology), Bob Langer (MIT, co-founder Moderna), Phil Greenberg (Hutch, co-founder Juno), Pam Sharma (MD Anderson), Charlie Rudin (Sloan Kettering), Alan Ashworth (UCSF Cancer Center).

Who You Are

  • You share our same sense of dedication, scientific passion and entrepreneurial spirit
  • You work well in a fast-paced and extremely focused startup environment
  • You are not only smart, but clever and constantly think outside the box
  • You are able to make logical decisions in an instant when there is little time to evaluate
  • You are a natural communicator and relationship builder
  • You stay calm under high pressure and stress
  • You have the ability to multi-task in a serious way, with an extreme attention to detail
  • You become a representative of the core DNA of the company through who you are

The Position

Earli is currently seeking a highly motivated and detail-oriented Research Associate to join the Therapeutics team. The successful candidate will play a key role in supporting sample processing and analysis to advance our research projects.

Your Primary Responsibilities

  • Extract DNA and RNA from both normal mouse tissues as well as cancer xenografts for the molecular analysis of Earli targets.
  • Execute experiments assessing target expression using array of methodologies including but limited to ELISA and RT-qPCR.
  • Process normal mouse tissues as well as cancer xenografts into single cell suspension for analysis of the tissue microenvironment by FACS.
  • Execute experiments assessing phenotype of normal mouse tissues and cancer xenograft microenvironments using 10+ color FACS panels.
  • Using sterile technique, maintain and scale up multiple cell lines for use in functional assays as well as protein production applications.
  • Analyze data and maintain accurate records of experimental procedures, data, and results in electronic lab notebooks and databases.

Your Required Experience, Knowledge and Skill

  • BS or MS degree in Cell Biology, Molecular Biology, or related sciences field with hands on wet lab experience.
  • Experience with basic tissue processing techniques and molecular biology methodologies (ELISA, RT-qPCR, agarose gel electrophoresis) is strongly preferred.
  • Experience if mammalian cell culture, cell-based assays (luminescence, fluorescence, etc.), and protein purification is a plus.
  • Strong analytical and problem-soling skills with the ability to troubleshoot experimental issues.
  • Excellent organizational skills and attention to detail, with the ability to manage multiple tasks simultaneously in a fast-paced environment.
  • Effective communication and interpersonal skills, with the ability to work collaboratively in a team setting.
  • A ‘self-starter’ mentality with strong motivation and a keen drive to excel individually and in a team.
  • Excellent verbal communication, organization, time management, and interpersonal skills.
  • Ability to think independently, multi-task effectively, and fully integrate into a high achieving team environment.

If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.

We look forward to hearing from you!