Senior Manager / Associate Director, IT Controls and Business Systems Applications
Apton Biosystems
PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.
About the Role
We are seeking a highly motivated and compliance-driven IT leader to oversee the Business Systems Applications function within our enterprise technology organization. This role is responsible for managing and evolving the systems that support core business operations — including SAP, Workday, MES, and related platforms — while ensuring strong governance, security, and compliance across all enterprise applications.
The Senior Manager/Associate Director, Business Systems Applications ensures that business systems are optimized to support company growth, operational excellence, and compliance with the Sarbanes-Oxley Act (SOX). The ideal candidate combines technical expertise, governance experience, and leadership ability, collaborating closely cross-functionally to scalable, well-controlled solutions.
Key Responsibilities
Business Systems Management
- Lead and mentor the Business Systems Applications team, including internal staff and external partners supporting SAP ERP, CamStar MES, Oracle Agile PLM, and related environments.
- Define the strategic roadmap for enterprise systems to support company growth and scalability.
- Oversee vendor relationships, licensing, and support contracts for enterprise applications.
- Manage change control processes including requirements definition, testing, approvals, and deployment.
- Champion data governance and master data integrity across systems.
- Drive continuous improvement initiatives through automation, standardization, and proactive monitoring of critical systems and validation processes.
Regulatory Compliance Ownership
- Own and operate IT General Controls (ITGCs) in-scope for SOX, including access management, change management, systems operations and logical security.
- Collaborate with Finance and Audit on control testing, remediation, and documentation.
- Maintain IT policies, narratives, and control matrices to support SOX compliance and external audit readiness.
- Support implementation and maintenance of Information Security Management System (ISMS) aligned with ISO 27001 standards, including ongoing risk assessments, access control governance, and system security audits for enterprise applications.
- Lead and maintain Computer System Validation (CSV) activities in accordance with FDA 21 CFR Part 11 and Part 820 requirements, ensuring that system implementation and changes meet IQ/OQ/PQ and documentation standards.
- Serve as the primary IT contact during internal, external, and regulatory audits.
Cross-Functional Collaboration
- Partner closely with the Director, Accounting Operations, to ensure business systems support accurate and timely financial reporting.
- Collaborate with Client Services, IT Infrastructure, HPC and Data Platform teams to align enterprise systems corporate architecture standards, security requirements, regulatory compliance requirements and operational support models.
- Lead or support cross-functional initiatives to streamline workflows, improve data flow, and enhance control efficiency.
Required Qualifications
- Bachelor’s degree in Information Systems, Computer Science, or related field; advanced degree preferred.
- 8+ years of progressive experience in business systems, enterprise applications, or IT leadership.
- 3+ years managing a team supporting ERP or financial systems in a regulated, SOX-compliant environment.
- Proven experience leading solution architecture for complex, integrated enterprise systems environments spanning on-premises and cloud infrastructures.
- Strong hands-on experience with SAP ECC 6.0 across multiple modules, including Finance (FI/CO), Sales (SD), and Logistics (MM/WM). Experience working knowledge of Agile PLM, Camstar MES and Workday.
- Deep expertise in SOX compliance, ITGC frameworks, Computer System Validation (CSV), and enterprise application controls.
- Demonstrated success leading audit, validation, and remediation efforts in regulated and public company environments.
- Strong ability to balance operational delivery with risk management and control discipline.
- Strong understanding of business processes, system dependencies, and internal control design.
- Experience leading cross-functional teams, managing third-party vendors, and supporting validated system environments.
- Excellent communication, stakeholder management, and organizational skills.
- Proven experience with automation, analytics, and digital transformation in validated environments.
- Hands-on leadership style, able to engage in both technical details and strategic initiatives.
Preferred Experience
- Exposure to Salesforce, SAP PI integration, and Snowflake is highly desirable.
- Awareness of leading cloud security standards and frameworks such as CSA, NIST, and ISO 27001 is highly desired.
Candidates must have current authorization to work in the United States without the need for present or future sponsorship.
Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite.
You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.
All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
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Salary Range:
$170,400.00 - $255,600.00
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All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or careers@pacificbiosciences.com for assistance.
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